Luxembourg has long been known as a leading European financial centre, but it’s also becoming a major source of research and innovation.
We are seeking two highly motivated post-doctoral researchers to study the spatio-temporal control of TGF beta signalling in epithelial cells. The project combines state-of-the-art cell biological (CRISPR/Cas9 genome editing), proteomics (multiplex quantitative proximity proteomics) and imaging (light and electron microscopy, correlative imaging, 3D tomography) techniques to address the role of endocytic trafficking in the regulation of this fundamental signalling pathway.
The project is a collaboration between the Dittmar laboratory at the Luxembourg Institute of Health (LIH) and the Sandin/Ludwig laboratory at the Nanyang Technological University (NTU) in Singapore, and so offers the unique opportunity to work in both Europe and Asia. Both laboratories have strong expertise in their respective fields and joined to understand how TGF beta signaling is regulated in time and space. Successful candidates will be employed at the LIH and have the opportunity to spend half of the project time in Singapore. The proteomics laboratory at LIH is equipped with the latest instrumentation in high-resolution mass spectrometry. Close collaborations with other groups at LIH offer a broad spectrum of additional cutting-edge techniques. The Sandin/Ludwig lab is part of the NTU Institute of Structural Biology (NISB), and is equipped with the latest high-end electron microscopes for cryoEM and cellular EM imaging (Titan Krios, Arctica), various light microscopes, and EM sample preparation equipment.
Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program as well as the possibility for close collaborations with the university and other research institutes.Continue reading