Hofkens’ group, the single molecule unit in the laboratory for photochemistry and spectroscopy (LPS), has long been active in the field of photochemistry and spectroscopy and has thus gained international recognition. LPS started to develop methodologies for studying ordered structures and their properties, including photophysical and/or photochemical processes, with a sub micron to molecular spatial resolution, fifteen years ago. Professor Hofkens and his team have been active in the field of single molecule spectroscopy for 10 years and the group is internationally recognized for their seminal contributions to the development of optical (single molecule) microscopy. The research group was also one of the first to realize that next-generation advances in imaging require the concerted optimization and improvement of not only the experimental hardware, but also the photophysics of the probes themselves, a finding that has become very clear with the new paradigm of ‘dynamic fluorescence’. This is especially obvious in the development of imaging modalities that make it possible to overcome the resolution limit in optical microscopy. To maintain its presence at the top of this research field, the LPS has introduced facilities that enable the engineering, expression, and characterization of switchable/ convertible fluorescent proteins using combined high- throughput and semi-rational approaches. The Hofkens group has recently developed a super-resolution DNA mapping technology, which complements sequencing and allows identification and quantification of genomic length DNA molecules at the single molecule level. The approach relies on enzymatic labelling of target DNA with fluorescent molecules in a sequence specific manner. Subsequent super-resolution fluorescence microscopy allows a 'barcode' of the genomic DNA to be created with unparalleled resolution. Further efforts are currently under way to extend the methodology allowing longer strands of DNA to be mapped, to create multi-color maps and/or to probe DNA methylation status. You will work in a fast paces and science-driven environment with the opportunity to interact with several internal and external groups. The applicant should be highly motivated and passionate in conducting research and associated laboratory tasks for projects and be able to work independently. Responsibilities include, design and execution of in vitro and cell-based experiments.
Contributing to various projects within the team byproposing novel and actionable ideas, aligned with internal and externalscientific strategies and demands. Activities will include:
Valued personal skills and competencies include but are not limited to:
Suitable candidates will initially receive remuneration conforming to the official Belgian salary scale for post-doctoral fellows but will also be required to apply for external funding as to maximize resources at the Hofkens group. Current Senior staff will assist candidates in these efforts based on their extensive knowledge of the BE funding landscape.
For more information please contact Prof. dr. Johan Hofkens, tel.: +32 16 32 78 04, mail: firstname.lastname@example.org or Dr. Kris Janssen, tel.: +32 16 37 94 75, mail: email@example.com.
You can apply for this job no later than February 15, 2018 via the online application tool
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